Carolyn Buser: search on Z-Library

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1

Dual Protein Farnesyltransferase−Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents

deSolms, S. Jane, Ciccarone, Terrence M., MacTough, Suzanne C., Shaw, Anthony W., Buser, Carolyn A., Ellis-Hutchings, Michelle, Fernandes, Christine, Hamilton, Kelly A., Huber, Hans E., Kohl, Nancy E.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

2

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP

Robert M. Garbaccio, Edward S. Tasber, Lou Anne Neilson, Paul J. Coleman, Mark E. Fraley, Christy Olson, Jeff Bergman, Maricel Torrent, Carolyn A. Buser, Keith Rickert, Eileen S. Walsh, Kelly Hamilton

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

3

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding

Mark E. Fraley, Kenneth L. Arrington, Carolyn A. Buser, Patrice A. Ciecko, Kathleen E. Coll, Christine Fernandes, George D. Hartman, William F. Hoffman, Joseph J. Lynch, Rosemary C. McFall, Keith Rick

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

4

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, Robert M. Garbaccio, Kenneth L. Arrington, William F. Hoffman, Edward S. Tasber, Paul J. Coleman, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Christine Fernandes, Michael D. Sch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

5

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Robert M. Garbaccio, Mark E. Fraley, Edward S. Tasber, Christy M. Olson, William F. Hoffman, Kenneth L. Arrington, Maricel Torrent, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Michael D. Schabe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

6

MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation

Li Wang, Kathy A. Mason, K. Kian Ang, Thomas Buchholz, David Valdecanas, Anjili Mathur, Carolyn Buser-Doepner, Carlo Toniatti, Luka Milas

Journal:

Investigational New Drugs

Year:

2012

Language:

english

File:

PDF, 240 KB

english, 2012

7

Methyl and t-Butyl Group Reorientation in Planar Aromatic Solids: Low-Frequency Nuclear Magnetic Resonance Relaxometry and X-Ray Diffraction

Peter A. Beckmann, Carolyn A. Buser, Kathleen Gullifer, Frank B. Mallory, Clelia W. Mallory, Gene M. Rossi, Arnold L. Rheingold

Journal:

Year:

2003

File:

PDF, 56 KB

2003

8

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

Christopher D. Cox, Michael J. Breslin, Brenda J. Mariano, Paul J. Coleman, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Hans E. Huber, Nancy E. Kohl, Maricel Torrent, Youwei Yan, Laurence C. Ku

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 169 KB

english, 2005

9

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

Anthony J. Roecker, Paul J. Coleman, Swati P. Mercer, John D. Schreier, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, Weikang Tao, Ronald E. Diehl, Vicki J. South, Joseph P. Dav

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 242 KB

english, 2007

10

Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity

Vadim Y. Dudkin, Cheng Wang, Kenneth L. Arrington, Mark E. Fraley, George D. Hartman, Steven M. Stirdivant, Robert A. Drakas, Keith Rickert, Eileen S. Walsh, Kelly Hamilton, Carolyn A. Buser, James Ha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.48 MB

english, 2012

11

Design and Biological Activity of ( S )-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Bell, Ian M., Gallicchio, Steven N., Abrams, Marc, Beshore, Douglas C., Buser, Carolyn A., Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 316 KB

english, 2001

12

Electron-transfer reactions in manganese-depleted photosystem II

Buser, Carolyn A., Thompson, Lynmarie K., Diner, Bruce A., Brudvig, Gary W.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

13

The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases

Thomas J Tucker, Marc T Abrams, Carolyn A Buser, Joseph P Davide, Michelle Ellis-Hutchings, Christine Fernandes, Jackson B Gibbs, Samuel L Graham, George D Hartman, Hans E Huber, Dongming Liu, Robert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 101 KB

english, 2002

14

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

C. Gary Marshall, Maricel Torrent, Olusegun Williams, Kelly A. Hamilton, Carolyn A. Buser

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 443 KB

english, 2009

15

Principal component-three component self-modeling analysis applied to trans-1,2-di(2-naphthyl)ethene fluorescence

Sun, Ya Ping., Sears, Donald F., Saltiel, Jack., Mallory, Frank B., Mallory, Clelia W., Buser, Carolyn A.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 1.25 MB

english, 1988

16

Corrigendum: The promise and peril of chemical probes

Arrowsmith, Cheryl H, Audia, James E, Austin, Christopher, Baell, Jonathan, Bennett, Jonathan, Blagg, Julian, Bountra, Chas, Brennan, Paul E, Brown, Peter J, Bunnage, Mark E, Buser-Doepner, Carolyn, C

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 97 KB

english, 2015

17

Reevaluation of the stoichiometry of cytochrome b559 in photosystem II and thylakoid membranes

Buser, Carolyn A., Diner, Bruce A., Brudvig, Gary W.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.03 MB

english, 1992

18

Electrostatics and the Membrane Association of Src: Theory and Experiment †

Murray, Diana, Hermida-Matsumoto, Luz, Buser, Carolyn A., Tsang, James, Sigal, Catherine T., Ben-Tal, Nir, Honig, Barry, Resh, Marilyn D., McLaughlin, Stuart

Journal:

Year:

1998

Language:

english

File:

PDF, 358 KB

english, 1998

19

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP

Christopher D. Cox, Maricel Torrent, Michael J. Breslin, Brenda J. Mariano, David B. Whitman, Paul J. Coleman, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Michael D. Schaber, Robert B. Lobell,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 314 KB

english, 2006

20

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Paul J. Coleman, John D. Schreier, Christopher D. Cox, Mark E. Fraley, Robert M. Garbaccio, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, Keith Rickert, Weikang Tao, Ronald E. D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

21

Photooxidation of cytochrome b559 in oxygen-evolving photosystem II

Buser, Carolyn A., Diner, Bruce A., Brudvig, Gary W.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.40 MB

english, 1992

22

Characterization of the multiple forms of cytochrome b559 in photosystem II

Thompson, Lynmarie K., Miller, Anne Frances, Buser, Carolyn A., De Paula, Julio C., Brudvig, Gary W.

Journal:

Year:

1989

Language:

english

File:

PDF, 1.17 MB

english, 1989

23

92nd Annual Meeting of the American Association for Cancer Research

Buser, Carolyn, Takaki, Tohru, Sepp-Lorenzino, Laura

Journal:

Expert Opinion on Investigational Drugs

Year:

2001

Language:

english

File:

PDF, 335 KB

english, 2001

24

Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Christopher J Dinsmore, C.Blair Zartman, Jeffrey M Bergman, Marc T Abrams, Carolyn A Buser, J.Christopher Culberson, Joseph P Davide, Michelle Ellis-Hutchings, Christine Fernandes, Samuel L Graham, Ge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

25

Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?

Buser, Carolyn A., Kim, Jiyun, McLaughlin, Stuart, Peitzsch, Robert M.

Journal:

Molecular Membrame Biology

Year:

1995

Language:

english

File:

PDF, 899 KB

english, 1995

26

Membrane Binding of Myristylated Peptides Corresponding to the NH2 Terminus of Src

Buser, Carolyn A., Sigal, Catherine T., Resh, Marilyn D., McLaughlin, Stuart

Journal:

Year:

1994

Language:

english

File:

PDF, 1.49 MB

english, 1994

27

EMT is the dominant program in human colon cancer

Andre Loboda, Michael V Nebozhyn, James W Watters, Carolyne A Buser, Peter Martin Shaw, Pearl S Huang, Laura Van’t Veer, Rob AEM Tollenaar, David B Jackson, Deepak Agrawal, Hongyue Dai, Timothy J Yeat

Journal:

BMC Medical Genomics

Year:

2011

Language:

english

File:

PDF, 1.81 MB

english, 2011

28

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Cox, Christopher D., Coleman, Paul J., Breslin, Michael J., Whitman, David B., Garbaccio, Robert M., Fraley, Mark E., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Schaber, Michael D., Lobell,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1010 KB

english, 2008

29

The promise and peril of chemical probes

Arrowsmith, Cheryl H, Audia, James E, Austin, Christopher, Baell, Jonathan, Bennett, Jonathan, Blagg, Julian, Bountra, Chas, Brennan, Paul E, Brown, Peter J, Bunnage, Mark E, Buser-Doepner, Carolyn, C

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 736 KB

english, 2015

30

Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein

Christopher D. Cox, Michael J. Breslin, David B. Whitman, Paul J. Coleman, Robert M. Garbaccio, Mark E. Fraley, Matthew M. Zrada, Carolyn A. Buser, Eileen S. Walsh, Kelly Hamilton, Robert B. Lobell, W

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 179 KB

english, 2007

31

Potent N -(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Bilodeau, Mark T., Balitza, Adrienne E., Koester, Timothy J., Manley, Peter J., Rodman, Leonard D., Buser-Doepner, Carolyn, Coll, Kathleen E., Fernandes, Christine, Gibbs, Jackson B., Heimbrook, David

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

32

High-Performance Liquid Chromatography/Mass Spectrometry Characterization of Ki4B-Ras in PSN-1 Cells Treated with the Prenyltransferase Inhibitor L-778,123

Carolyn A. Buser, Christopher J. Dinsmore, Christine Fernandes, Ian Greenberg, Kelly Hamilton, Scott D. Mosser, Eileen S. Walsh, Theresa M. Williams, Kenneth S. Koblan

Journal:

Analytical Biochemistry

Year:

2001

Language:

english

File:

PDF, 179 KB

english, 2001

33

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase

John T. Sisko, Thomas J. Tucker, Mark T. Bilodeau, Carolyn A. Buser, Patrice A. Ciecko, Kathleen E. Coll, Christine Fernandes, Jackson B. Gibbs, Timothy J. Koester, Nancy Kohl, Joseph J. Lynch, Xianzh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 127 KB

english, 2006

34

Methyl and t-butyl group reorientation in planar aromatic solids: Low-frequency nuclear magnetic resonance relaxometry and x-ray diffraction

Beckmann, Peter A., Buser, Carolyn A., Gullifer, Kathleen, Mallory, Frank B., Mallory, Clelia W., Rossi, Gene M., Rheingold, Arnold L.

Journal:

The Journal of Chemical Physics

Year:

2003

Language:

english

File:

PDF, 376 KB

english, 2003

35

In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465

Joseph M. Negri, Douglas W. McMillin, Jake Delmore, Nicholas Mitsiades, Patrick Hayden, Steffen Klippel, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Carolyn A. Buser, John Pollard, Paul G. R

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 351 KB

english, 2009

36

Calcium binding site(s) of Photosystem II as probed by lanthanides

Alexandra Bakou, Carolyn Buser, Gregory Dandulakis, Gary Brudvig, Demetrios F. Ghanotakis

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1992

Language:

english

File:

PDF, 459 KB

english, 1992

37

Methyl reorientation in solid 3-ethylchrysene and 3-isopropylchrysene

Peter A. Beckmann, Carolyn A. Buser, Clelia W. Mallory, Frank B. Mallory, Jennifer Mosher

Journal:

Solid State Nuclear Magnetic Resonance

Year:

1998

Language:

english

File:

PDF, 113 KB

english, 1998

38

3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Bell, Ian M., Gallicchio, Steven N., Abrams, Marc, Beese, Lorena S., Beshore, Douglas C., Bhimnathwala, Hema, Bogusky, Michael J., Buser, Carolyn A., Culberson, J. Christopher, Davide, Joseph, Ellis-H

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 877 KB

english, 2002

39

Amino-Terminal Basic Residues of Src Mediate Membrane Binding Through Electrostatic Interaction with Acidic Phospholipids

Catherine T. Sigal, Wenjun Zhou, Carolyn A. Buser, Stuart McLaughlin and Marilyn D. Resh

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

40

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

Bridges, Kathleen A., Toniatti, Carlo, Buser, Carolyn A., Liu, Huifeng, Buchholz, Thomas A., Meyn, Raymond E.

Journal:

Year:

2014

Language:

english

File:

PDF, 791 KB

english, 2014

41

Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Jeffrey M Bergman, Marc T Abrams, Joseph P Davide, Ian B Greenberg, Ronald G Robinson, Carolyn A Buser, Hans E Huber, Kenneth S Koblan, Nancy E Kohl, Robert B Lobell, Samuel L Graham, George D Hartman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

42

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Youwei Yan, Vinod Sardana, Bei Xu, Carl Homnick, Wasyl Halczenko, Carolyn A. Buser, Michael Schaber, George D. Hartman, Hans E. Huber, Lawrence C. Kuo

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.51 MB

english, 2004

43

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

Shaei Huang, Robert M. Garbaccio, Mark E. Fraley, Justin Steen, Constantine Kreatsoulas, George Hartman, Steve Stirdivant, Bob Drakas, Keith Rickert, Eileen Walsh, Kelly Hamilton, Carolyn A. Buser, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

44

2-Arylindole-3-acetamides: FPP-Competitive inhibitors of farnesyl protein transferase

B.Wesley Trotter, Amy G. Quigley, William C. Lumma, John T. Sisko, Eileen S. Walsh, Christian S. Hamann, Ronald G. Robinson, Hema Bhimnathwala, D.Garrett Kolodin, Wei Zheng, Carolyn A. Buser, Hans E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

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